谷春雨 神经肿瘤外科专家

个人简历

神经外科博士，留美博士后，主任医师，1999于中国医科大学获临床医学学士学位;2003年于中国医科大学获神经外科硕士学位; 同年于中国医科大学附属盛京医院神经外科工作，2005年留学日本就读于日本浜松医科大学神经外科，2010年获得医学博士学位。同年留学美国俄亥俄州立大学医学院神经外科做博士后研究工作。2012年回国，在首都医科大学三博脑科医院神经外科颅底肿瘤病区工作至今，任颅底病区副主任。长期从事神经系统脑肿瘤的临床和研究工作，在脑肿瘤诊断、手术治疗方面有丰富的临床经验。

代表性文章

1.Liu H, Sun Y, Qi X, Gordon RE, O'Brien JA, Yuan H, Zhang J, Wang Z, Zhang M, Song Y, Yu C, Gu C: EZH2 Phosphorylation Promotes Self-Renewal of Glioma Stem-Like Cells Through NF-κB Methylation. Front Oncol. 2019 Jul 16;9:641.

2.Liu H, Sun Q, Sun Y, Zhang J, Yuan H, Pang S, Qi X, Wang H, Zhang M, Zhang H, Yu C, Gu C：MELK and EZH2 Cooperate to Regulate Medulloblastoma Cancer Stem-like Cell Proliferation and Differentiation. Mol Cancer Res. 2017 Sep;15(9):1275-1286.

3. Zhang M, Wang Z, Zhang J, Zhang H, Gu C, Wang H, Yu C, Wu H：Metastases in cerebellopontine angle from the tumors of central nerve system. J Clin Neurosci. 2017 Aug;42:84-90.

4. Kim SH, Joshi K, Ezhilarasan R, Myers TR, Siu J, Gu C, Nakano-Okuno M, Taylor D, Minata M, Sulman EP, Lee J, Bhat KP, Salcini AE, Nakano I: EZH2 protects glioma stem cells from radiation-induced cell death in a MELK/FOXM1-dependent manner. Stem Cell Reports. 2015 Feb 10;4(2):226-38.

5. Minata M, Gu C, Joshi K, Nakano-Okuno M, Hong C, Nguyen CH, Kornblum HI, Molla A, Nakano I: Multi-kinase inhibitor C1 triggers mitotic catastrophe of glioma stem cells mainly through MELK kinase inhibition. PLoS One. 2014 Apr 16;9(4):e92546.

6. Gu C, Banasavadi-Siddegowda YK, Joshi K, Nakamura Y, Kurt H, Gupta S, Nakano I: Tumor-Specific Activation of the C-JUN/MELK Pathway Regulates Glioma Stem Cell Growth in a p53-Dependent Manner. Stem Cell. 2013 May;31(5):870-81.

7. Li S, Gu C, Gao Y, Amano S, Koizumi S, Tokuyama T, Namba H: Bystander effect in glioma suicide gene therapy using bone marrow stromal cells. Stem Cell Res. 2012 Nov;9(3):270-6.

8. Gu C, Yokota N, Gao Y, Amano S, Koizumi S, Tokuyama T, Namba H: Targeting therapy against promyelocytic leukemia gene using arsenic acids in experimental intracranial medulloblastoma. Neurologia medico-chirurgica, 2012;52(2):62-7.

9. Amano S, Gu C, Koizumi S, Tokuyama T, Namba H:　Tumoricidal bystander effect in the suicide gene therapy using mesenchymal stem cells does not injure normal brain tissues. Cancer Lett. 2011 Jul 1;306(1):99-105.

10. Amano S, Gu C, Koizumi S, Tokuyama T, Namba H：Timing of ganciclovir administration in glioma gene therapy using HSVtk gene-transduced mesenchymal stem cells. Cancer Genomics Proteomics. 2011 Sep-Oct;8(5):245-50.

11. Koizumi S, Gu C, Amano S, Yamamoto S, Ihara H, Tokuyama T, Namba H：Migration of mouse-induced pluripotent stem cells to glioma-conditioned medium is mediated by tumor-associated specific growth factors. Oncol Lett. 2011 Mar;2(2):283-288.

12. Gu C, Yokota N, Gao Y, Yamamoto J, Tokuyama T, Namba H: Gene expression of growth signaling pathways is up-regulated in CD133-positive medulloblastoma cells. Oncol Lett. 2011 Mar;2(2):357-361.

13. Gao Y, Gu C, Li S, Tokuyama T, Yokota N, Nakayama KI, Kitagawa M, Namba H：p27 modulates tropism of mesenchymal stem cells toward brain tumors. Exp Ther Med. 2010 Jul;1(4):695-699.

14. Gu C, Li S, Tokuyama T, Yokota N, Namba H: Therapeutic effect of genetically engineered mesenchymal stem cells in rat experimental leptomeningeal glioma model. Cancer Lett. 291: 256–262, 2010.

15. Amano S, Li S, Gu C, Gao Y, Koizumi S, Yamamoto S, Terakawa S, Namba H: Tumoricidal bystander effect-mediated suicide gene therapy of glioma using genetically engineered bone marrow-drived mesenchymal stem cells. Int J Oncol. 35: 1265-1270, 2009.